Evid Based Ment Health. 2009 Nov;12(4):98-100
Danube University, Department for Evidence-based Medicine and Clinical Epidemiology, Krems, Austria. gerald.gartlehner@donau-uni.ac.at
Primary care physicians and psychiatrists manage the majority of patients suffering from acute phase major depressive disorder (MDD). For most patients, antidepressant treatment is the primary choice of care. Second generation antidepressants (SGAs)—developed following the first generation of tricyclic and monoamine oxidase agents—have become the preferred drug choice because of their greater tolerability, lower risk of lethality and similar efficacy compared with first generation agents. (More)